4WI4

Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation S254A

Summary for 4WI4

• Entry DOI: 10.2210/pdb4wi4/pdb
• Descriptor: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: human igg1, fcrn binding site, therapeutic antibody, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 50236.15

Authors

Farrugia, W.,Burvenich, I.J.G.,Scott, A.M.,Ramsland, P.A. (deposition date: 2014-09-25, release date: 2015-09-30, Last modification date: 2023-12-27)

• Primary citation: Burvenich, I.J.G.,Farrugia, W.,Lee, F.T.,Catimel, B.,Liu, Z.,Makris, D.,Cao, D.,O'Keefe, G.,Brechbiel, M.W.,King, D.,Spirkoska, V.,Allan, L.,Ramsland, P.A.,Scott, A.M.; Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)