4WH9

Structure of the CDC25B Phosphatase Catalytic Domain with Bound Inhibitor

Summary for 4WH9

Entry DOI	10.2210/pdb4wh9/pdb
Related	4WH7
Descriptor	M-phase inducer phosphatase 2, 2-[(2-cyano-3-fluoro-5-hydroxyphenyl)sulfanyl]ethanesulfonic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	phosphatase, inhibitor, fragment, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	22203.06
Authors	Lund, G.L.,Dudkin, S.,Borkin, D.,Ni, W.,Grembecka, J.,Cierpicki, T. (deposition date: 2014-09-20, release date: 2014-12-10, Last modification date: 2023-09-27)
Primary citation	Lund, G.,Dudkin, S.,Borkin, D.,Ni, W.,Grembecka, J.,Cierpicki, T. Inhibition of CDC25B Phosphatase Through Disruption of Protein-Protein Interaction. Acs Chem.Biol., 10:390-394, 2015 Cited by PubMed: 25423142 DOI: 10.1021/cb500883h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation