4WEG

influenza virus neuraminidase N9 in complex 2,3-difluorosialic acid

4WEG の概要

• エントリーDOI: 10.2210/pdb4weg/pdb
• 関連するPDBエントリー: 1NNC 4WEF
• 分子名称: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: influenza virus neuraminidase, n9, complex, 2, 3-difluorosialic acid, second binding site, hydrolase
• 由来する生物種: Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
• 細胞内の位置: Virion membrane : P03472
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46772.46

構造登録者

Streltsov, V.A.,Pilling, P.,Barrett, S.,McKimm-Breschkin, J. (登録日: 2014-09-10, 公開日: 2015-09-16, 最終更新日: 2020-07-29)

• 主引用文献: Streltsov, V.A.,Pilling, P.,Barrett, S.,McKimm-Breschkin, J.L.; Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN); Antiviral Res., 123:216-223, 2015; PubMed: 26364554; DOI: 10.1016/j.antiviral.2015.08.014

実験手法

X-RAY DIFFRACTION (2.1 Å)