4WBH

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I APO - 2.2A

Summary for 4WBH

• Entry DOI: 10.2210/pdb4wbh/pdb
• Descriptor: Protein notum homolog, CHLORIDE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: wnt, extracellular esterase, alpha/beta hydrolase, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : Q6P988
• Total number of polymer chains: 2
• Total formula weight: 106656.87

Authors

Zebisch, M.,Jones, E.Y. (deposition date: 2014-09-03, release date: 2015-02-25, Last modification date: 2020-07-29)

• Primary citation: Kakugawa, S.,Langton, P.F.,Zebisch, M.,Howell, S.A.,Chang, T.-H.,Liu, Y.,Feizi, T.,Bineva, G.,O'Reilly, N.,Snijders, A.P.,Jones, E.Y.,Vincent, J.-P.; Notum deacylates Wnt proteins to suppress signalling activity; Nature, 519:187-192, 2015; PubMed: 25731175; DOI: 10.1038/nature14259

Experimental method

X-RAY DIFFRACTION (2.2 Å)