4WB2

Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin

4WB2 の概要

• エントリーDOI: 10.2210/pdb4wb2/pdb
• 分子名称: Complement C5, mixed L-RNA/L-DNA mirror-image aptamer NOX-D20 (40-MER), ACETATE ION, ... (6 entities in total)
• 機能のキーワード: protein-rna complex, mirror-image aptamer, g-quadruplex, complement anaphylatoxin, dna-rna hybrid
• 由来する生物種: Mus musculus (House Mouse); 詳細
• 細胞内の位置: Secreted: P06684
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 53699.52

構造登録者

Yatime, L.,Maasch, C.,Hoehlig, K.,Klussmann, S.,Vater, A.,Andersen, G.R. (登録日: 2014-09-02, 公開日: 2015-05-06, 最終更新日: 2023-07-26)

• 主引用文献: Yatime, L.,Maasch, C.,Hoehlig, K.,Klussmann, S.,Andersen, G.R.,Vater, A.; Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.; Nat Commun, 6:6481-6481, 2015; PubMed: 25901944; DOI: 10.1038/ncomms7481

実験手法

X-RAY DIFFRACTION (1.8 Å)