4WAB
Crystal structure of mPGES1 solved by native-SAD phasing
Summary for 4WAB
Entry DOI | 10.2210/pdb4wab/pdb |
Descriptor | Prostaglandin E synthase,Leukotriene C4 synthase, GLUTATHIONE, 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, ... (4 entities in total) |
Functional Keywords | native-sad, isomerase, cancer, drug target, in meso crystallization, inflammation, inhibitor, leukotriene c4 synthase, lipid metabolism, membrane-associated proteins in eicosanoid and glutathione metabolism, mapag, membrane protein, mpges1, pain, microcrystal, anomalous dispersion, sulfur-sad, s-sad |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 21286.73 |
Authors | Weinert, T.,Li, D.,Howe, N.,Caffrey, M.,Wang, M. (deposition date: 2014-08-29, release date: 2014-12-10, Last modification date: 2024-05-08) |
Primary citation | Weinert, T.,Olieric, V.,Waltersperger, S.,Panepucci, E.,Chen, L.,Zhang, H.,Zhou, D.,Rose, J.,Ebihara, A.,Kuramitsu, S.,Li, D.,Howe, N.,Schnapp, G.,Pautsch, A.,Bargsten, K.,Prota, A.E.,Surana, P.,Kottur, J.,Nair, D.T.,Basilico, F.,Cecatiello, V.,Pasqualato, S.,Boland, A.,Weichenrieder, O.,Wang, B.C.,Steinmetz, M.O.,Caffrey, M.,Wang, M. Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12:131-133, 2015 Cited by PubMed: 25506719DOI: 10.1038/nmeth.3211 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.704 Å) |
Structure validation
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