4WAB

Crystal structure of mPGES1 solved by native-SAD phasing

4WAB の概要

• エントリーDOI: 10.2210/pdb4wab/pdb
• 分子名称: Prostaglandin E synthase,Leukotriene C4 synthase, GLUTATHIONE, 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, ... (4 entities in total)
• 機能のキーワード: native-sad, isomerase, cancer, drug target, in meso crystallization, inflammation, inhibitor, leukotriene c4 synthase, lipid metabolism, membrane-associated proteins in eicosanoid and glutathione metabolism, mapag, membrane protein, mpges1, pain, microcrystal, anomalous dispersion, sulfur-sad, s-sad
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21286.73

構造登録者

Weinert, T.,Li, D.,Howe, N.,Caffrey, M.,Wang, M. (登録日: 2014-08-29, 公開日: 2014-12-10, 最終更新日: 2024-05-08)

• 主引用文献: Weinert, T.,Olieric, V.,Waltersperger, S.,Panepucci, E.,Chen, L.,Zhang, H.,Zhou, D.,Rose, J.,Ebihara, A.,Kuramitsu, S.,Li, D.,Howe, N.,Schnapp, G.,Pautsch, A.,Bargsten, K.,Prota, A.E.,Surana, P.,Kottur, J.,Nair, D.T.,Basilico, F.,Cecatiello, V.,Pasqualato, S.,Boland, A.,Weichenrieder, O.,Wang, B.C.,Steinmetz, M.O.,Caffrey, M.,Wang, M.; Fast native-SAD phasing for routine macromolecular structure determination.; Nat.Methods, 12:131-133, 2015; PubMed: 25506719; DOI: 10.1038/nmeth.3211

実験手法

X-RAY DIFFRACTION (2.704 Å)