4W5I
Crystal structure of human tankyrase 2 in complex with 1-methyl-7-phenyl-1,2,3,4,5,6-hexahydro-1,6- naphthyridin-5-one
Summary for 4W5I
Entry DOI | 10.2210/pdb4w5i/pdb |
Descriptor | Tankyrase-2, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 2 |
Total formula weight | 55687.29 |
Authors | Haikarainen, T.,Lehtio, L. (deposition date: 2014-08-18, release date: 2015-06-10, Last modification date: 2024-05-08) |
Primary citation | Kumpan, K.,Nathubhai, A.,Zhang, C.,Wood, P.J.,Lloyd, M.D.,Thompson, A.S.,Haikarainen, T.,Lehtio, L.,Threadgill, M.D. Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. Bioorg.Med.Chem., 23:3013-3032, 2015 Cited by PubMed: 26026769DOI: 10.1016/j.bmc.2015.05.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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