4W1V

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a thiazole inhibitor

Summary for 4W1V

Entry DOI	10.2210/pdb4w1v/pdb
Related	4W1W 4W1X
Descriptor	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, dimethyl (2R)-5-(3-fluorophenyl)-1H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate 2-oxide, ... (7 entities in total)
Functional Keywords	inhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm : P9WQ80
Total number of polymer chains	2
Total formula weight	92891.44
Authors	Finzel, B.C.,Dai, R. (deposition date: 2014-08-13, release date: 2015-02-04, Last modification date: 2023-12-27)
Primary citation	Park, S.W.,Casalena, D.E.,Wilson, D.J.,Dai, R.,Nag, P.P.,Liu, F.,Boyce, J.P.,Bittker, J.A.,Schreiber, S.L.,Finzel, B.C.,Schnappinger, D.,Aldrich, C.C. Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis. Chem.Biol., 22:76-86, 2015 Cited by PubMed: 25556942 DOI: 10.1016/j.chembiol.2014.11.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation