4V4Q

Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution.

これはPDB形式変換不可エントリーです。

4V4Q の概要

• エントリーDOI: 10.2210/pdb4v4q/pdb
• 関連するPDBエントリー: 2AW4 2AW7 2AWB
• 分子名称: 16S ribosomal RNA, 30S ribosomal protein S11, 30S ribosomal protein S12, ... (54 entities in total)
• 機能のキーワード: rna-protein complex, 30s ribosomal subunit, ribosome
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 104
• 化学式量合計: 4293421.75

構造登録者

Schuwirth, B.S.,Borovinskaya, M.A.,Hau, C.W.,Zhang, W.,Vila-Sanjurjo, A.,Holton, J.M.,Cate, J.H.D. (登録日: 2005-08-30, 公開日: 2014-07-09, 最終更新日: 2023-09-20)

主引用文献

Schuwirth, B.S.,Borovinskaya, M.A.,Hau, C.W.,Zhang, W.,Vila-Sanjurjo, A.,Holton, J.M.,Cate, J.H.
Structures of the bacterial ribosome at 3.5 A resolution.
Science, 310:827-834, 2005

PubMed Abstract: We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the interface between the small and large ribosomal subunits and the conformation of the peptidyl transferase center in the context of the intact ribosome. Differences between the two ribosomes reveal a high degree of flexibility between the head and the rest of the small subunit. Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA (mRNA) and transfer RNAs (tRNAs) during translocation.

PubMed: 16272117
DOI: 10.1126/science.1117230

実験手法

X-RAY DIFFRACTION (3.46 Å)