4V3M

Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link

Summary for 4V3M

• Entry DOI: 10.2210/pdb4v3m/pdb
• Related: 4V2T 4V3A 4V3N
• EMDB information: 2795
• Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B (2 entities in total)
• Functional Keywords: transport protein, macpf/cdc superfamily, pore-forming proteins
• Biological source: PLEUROTUS OSTREATUS (OYSTER MUSHROOM); More
• Total number of polymer chains: 3
• Total formula weight: 86866.09

Authors

Lukoyanova, N.,Kondos, S.C.,Farabella, I.,Law, R.H.P.,Reboul, C.F.,Caradoc-Davies, T.T.,Spicer, B.A.,Kleifeld, O.,Perugini, M.,Ekkel, S.,Hatfaludi, T.,Oliver, K.,Hotze, E.M.,Tweten, R.K.,Whisstock, J.C.,Topf, M.,Dunstone, M.A.,Saibil, H.R. (deposition date: 2014-10-20, release date: 2015-02-18, Last modification date: 2017-08-23)

• Primary citation: Lukoyanova, N.,Kondos, S.C.,Farabella, I.,Law, R.H.P.,Reboul, C.F.,Caradoc-Davies, T.T.,Spicer, B.A.,Kleifeld, O.,Traore, D.A.K.,Ekkel, S.M.,Voskoboinik, I.,Trapani, J.A.,Hatfaludi, T.,Oliver, K.,Hotze, E.M.,Tweten, R.K.,Whisstock, J.C.,Topf, M.,Saibil, H.R.,Dunstone, M.A.; Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.; Plos Biol., 13:02049-, 2015; PubMed: 25654333; DOI: 10.1371/JOURNAL.PBIO.1002049

Experimental method

ELECTRON MICROSCOPY (17 Å)