4V2W

JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (16-35)

4V2W の概要

• エントリーDOI: 10.2210/pdb4v2w/pdb
• 関連するPDBエントリー: 4V2V
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, NICKEL (II) ION, ... (8 entities in total)
• 機能のキーワード: jmjd2a, oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, double-stranded beta helix, dsbh, facial triad, demethylase, histone, jmjc domain, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 91413.37

構造登録者

Chowdhury, R.,Zafred, D.,Schofield, C.J. (登録日: 2014-10-15, 公開日: 2014-11-26, 最終更新日: 2024-01-10)

• 主引用文献: Williams, S.T.,Walport, L.J.,Hopkinson, R.J.,Madden, S.K.,Chowdhury, R.,Schofield, C.J.,Kawamura, A.; Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.; Epigenetics, 9:1596-, 2014; PubMed: 25625844; DOI: 10.4161/15592294.2014.983381

実験手法

X-RAY DIFFRACTION (1.81 Å)