4V10
Skelemin Association with alpha2b,beta3 Integrin: A Structural Model
Summary for 4V10
| Entry DOI | 10.2210/pdb4v10/pdb |
| NMR Information | BMRB: 25242 |
| Descriptor | MYOMESIN-1 (1 entity in total) |
| Functional Keywords | structural protein, integrin |
| Biological source | MUS MUSCULUS (HOUSE MOUSE) |
| Cellular location | Cytoplasm, myofibril, sarcomere, M line : Q62234 |
| Total number of polymer chains | 1 |
| Total formula weight | 27092.94 |
| Authors | Gorbatyuk, V.,Deshmukh, L.,Nguyen, K.,Vinogradova, O. (deposition date: 2014-09-19, release date: 2014-10-08, Last modification date: 2024-06-19) |
| Primary citation | Gorbatyuk, V.,Nguyen, K.,Podolnikova, N.P.,Deshmukh, L.,Lin, X.,Ugarova, T.P.,Vinogradova, O. Skelemin Association with Alphaiibbeta3 Integrin: A Structural Model. Biochemistry, 53:6766-6775, 2014 Cited by PubMed Abstract: Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin αIIbβ3. The model of tertiary assembly is generated based upon NMR data and illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling. PubMed: 25224262DOI: 10.1021/BI500680S PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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