4UZ7

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM VI - 2.2A

Summary for 4UZ7

Entry DOI	10.2210/pdb4uz7/pdb
Related	4UYU 4UYW 4UYZ 4UZ1 4UZ5 4UZ6 4UZ9 4UZA 4UZJ 4UZK 4UZL 4UZQ
Descriptor	PROTEIN NOTUM HOMOLOG, CHLORIDE ION (3 entities in total)
Functional Keywords	hydrolase, wnt, esterase, extracellular, alpha/beta hydrolase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Secreted : Q6P988
Total number of polymer chains	2
Total formula weight	87169.75
Authors	Zebisch, M.,Jones, E.Y. (deposition date: 2014-09-04, release date: 2015-02-25, Last modification date: 2015-03-18)
Primary citation	Kakugawa, S.,Langton, P.F.,Zebisch, M.,Howell, S.A.,Chang, T.,Liu, Y.,Feizi, T.,Bineva, G.,O'Reilly, N.,Snijders, A.P.,Jones, E.Y.,Vincent, J. Notum Deacylates Wnt Proteins to Suppress Signalling Activity. Nature, 519:187-, 2015 Cited by PubMed: 25731175 DOI: 10.1038/NATURE14259 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation