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4UYW

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I HEPARIN FRAGMENT COMPLEX - 1.7A

Summary for 4UYW
Entry DOI10.2210/pdb4uyw/pdb
Related4UYU 4UYZ 4UZ1 4UZ5 4UZ6 4UZ7 4UZ9 4UZA 4UZJ 4UZK 4UZL 4UZQ 4WBH
Related PRD IDPRD_900026
DescriptorPROTEIN NOTUM HOMOLOG, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywordshydrolase, wnt, esterase, extracellular, alpha/beta hydrolase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted : Q6P988
Total number of polymer chains2
Total formula weight88154.18
Authors
Zebisch, M.,Jones, E.Y. (deposition date: 2014-09-03, release date: 2015-02-25, Last modification date: 2020-07-29)
Primary citationKakugawa, S.,Langton, P.F.,Zebisch, M.,Howell, S.A.,Chang, T.,Liu, Y.,Feizi, T.,Bineva, G.,O'Reilly, N.,Snijders, A.P.,Jones, E.Y.,Vincent, J.
Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519:187-, 2015
Cited by
PubMed: 25731175
DOI: 10.1038/NATURE14259
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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