4UYW

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I HEPARIN FRAGMENT COMPLEX - 1.7A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	PROTEIN NOTUM HOMOLOG	polymer	383	43567.1	2	UniProt (Q6P988) Pfam (PF03283) In PDB	HOMO SAPIENS (HUMAN)
2	C	4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose	branched		577.5	1	In PDB BIRD (PRD_900026) GlyTouCan (G01871HO)		HEPARIN DISACCHARIDE I-S,
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4		water	water		18.0	474	Chemie (HOH)

Sequence modifications

A, B: 81 - 451 (UniProt: Q6P988)

PDB	External Database	Details
Glu 78	-	expression tag
Thr 79	-	expression tag
Gly 80	-	expression tag
Gly 452	-	expression tag
Thr 453	-	expression tag
Lys 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag
Ser 330	Cys 330	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87134.3
Branched	Number of molecules	1
	Total formula weight	577.5
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	88154.2

*Water molecules are not included.