4UX4

Crystal structure of human tankyrase 2 in complex with 1-methyl-7-(4- methylphenyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-1-ium

4UX4 の概要

• エントリーDOI: 10.2210/pdb4ux4/pdb
• 分子名称: TANKYRASE-2, (1S)-1-methyl-7-(4-methylphenyl)-5-oxo-1,5-dihydro-1,6-naphthyridin-1-ium, ZINC ION, ... (6 entities in total)
• 機能のキーワード: transferase, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55801.39

構造登録者

Haikarainen, T.,Lehtio, L. (登録日: 2014-08-19, 公開日: 2015-06-10, 最終更新日: 2024-05-08)

• 主引用文献: Kumpan, K.,Nathubhai, A.,Zhang, C.,Wood, P.J.,Lloyd, M.D.,Thompson, A.S.,Haikarainen, T.,Lehtio, L.,Threadgill, M.D.; Structure-Based Design, Synthesis and Evaluation in Vitro of Arylnaphthyridinones, Arylpyridopyrimidinones and Their Tetrahydro Derivatives as Inhibitors of the Tankyrases.; Bioorg.Med.Chem., 23:3013-, 2015; PubMed: 26026769; DOI: 10.1016/J.BMC.2015.05.005

実験手法

X-RAY DIFFRACTION (1.8 Å)