4UWD

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) D315E VARIANT in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)

Summary for 4UWD

• Entry DOI: 10.2210/pdb4uwd/pdb
• Related: 3HQR 4BQX 4BQY
• Descriptor: EGL NINE HOMOLOG 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 28446.57

Authors

Chowdhury, R.,Tarhonskaya, H.,Schofield, C.J. (deposition date: 2014-08-11, release date: 2014-08-27, Last modification date: 2024-01-10)

• Primary citation: Tarhonskaya, H.,Chowdhury, R.,Leung, I.K.H.,Loik, N.D.,Mccullagh, J.S.O.,Claridge, T.D.W.,Schofield, C.J.,Flashman, E.; Investigating the Contribution of the Active Site Environment to the Slow Reaction of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 with Oxygen.; Biochem.J., 463:363-, 2014; PubMed: 25120187; DOI: 10.1042/BJ20140779

Experimental method

X-RAY DIFFRACTION (1.721 Å)