4UW1

X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

Summary for 4UW1

• Entry DOI: 10.2210/pdb4uw1/pdb
• Related: 4UUH
• Descriptor: TANKYRASE-1, ZINC ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: transferase, tnks, inhibitor, wnt signalling
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: O95271
• Total number of polymer chains: 8
• Total formula weight: 238789.41

Authors

Oliver, A.W.,Rajasekaran, M.B.,Pearl, L.H. (deposition date: 2014-08-08, release date: 2015-07-08, Last modification date: 2024-01-10)

• Primary citation: Elliot, R.J.,Jarvis, A.,Rajasekaran, M.B.,Menon, M.,Bowers, L.,Boffey, R.,Bayford, M.,Firth-Clark, S.,Beevers, R.,Aquil, R.,Kirton, S.B.,Niculescu-Duvaz, D.,Fish, L.,Lopes, F.,Mcleary, R.,Trindade, I.,Vendrell, E.,Munkonge, F.,Porter, R.,Perrior, T.,Springer, C.,Oliver, A.W.,Pearl, L.H.,Ashworth, A.,Lord, C.J.; Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors; Medchemcommm, 6:1687-, 2015; DOI: 10.1039/C5MD00210A

Experimental method

X-RAY DIFFRACTION (3.37 Å)