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4UUQ

Crystal structure of human mono-glyceride lipase in complex with SAR127303

Summary for 4UUQ
Entry DOI10.2210/pdb4uuq/pdb
DescriptorMONOGLYCERIDE LIPASE, 4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid (3 entities in total)
Functional Keywordshydrolase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight71250.63
Authors
Primary citationGriebel, G.,Pichat, P.,Beeske, S.,Leroy, T.,Redon, N.,Jacquet, A.,Francon, D.,Bert, L.,Even, L.,Lopez-Grancha, M.,Tolstykh, T.,Sun, F.,Yu, Q.,Brittain, S.,Arlt, H.,He, T.,Zhang, B.,Wiederschain, D.,Bertrand, T.,Houtmann, J.,Rak, A.,Vallee, F.,Michot, N.,Auge, F.,Menet, V.,Bergis, O.E.,George, P.,Avenet, P.,Mikol, V.,Didier, M.,Escoubet, J.
Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents.
Sci.Rep., 5:7642-, 2015
Cited by
PubMed: 25560837
DOI: 10.1038/SREP07642
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.36 Å)
Structure validation

217705

數據於2024-03-27公開中

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