4UUQ
Crystal structure of human mono-glyceride lipase in complex with SAR127303
Summary for 4UUQ
Entry DOI | 10.2210/pdb4uuq/pdb |
Descriptor | MONOGLYCERIDE LIPASE, 4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid (3 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 71250.63 |
Authors | Griebel, G.,Pichat, P.,Beeske, S.,Leroy, T.,Redon, N.,Francon, D.,Bert, L.,Even, L.,Lopez-Grancha, M.,Tolstykh, T.,Sun, F.,Yu, Q.,Brittain, S.,Arlt, H.,He, T.,Zhang, B.,Wiederschain, D.,Bertrand, T.,Houtman, J.,Rak, A.,Vallee, F.,Michot, N.,Auge, F.,Menet, V.,Bergis, O.E.,George, P.,Avenet, P.,Mikol, V.,Didier, M.,Escoubet, J. (deposition date: 2014-07-30, release date: 2015-01-21, Last modification date: 2024-01-10) |
Primary citation | Griebel, G.,Pichat, P.,Beeske, S.,Leroy, T.,Redon, N.,Jacquet, A.,Francon, D.,Bert, L.,Even, L.,Lopez-Grancha, M.,Tolstykh, T.,Sun, F.,Yu, Q.,Brittain, S.,Arlt, H.,He, T.,Zhang, B.,Wiederschain, D.,Bertrand, T.,Houtmann, J.,Rak, A.,Vallee, F.,Michot, N.,Auge, F.,Menet, V.,Bergis, O.E.,George, P.,Avenet, P.,Mikol, V.,Didier, M.,Escoubet, J. Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents. Sci.Rep., 5:7642-, 2015 Cited by PubMed: 25560837DOI: 10.1038/SREP07642 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
Download full validation report