4USE

Human STK10 (LOK) with SB-633825

Summary for 4USE

• Entry DOI: 10.2210/pdb4use/pdb
• Related: 4USD 4USF
• Descriptor: SERINE/THREONINE-PROTEIN KINASE 10, 4-{5-(6-methoxynaphthalen-2-yl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl}pyridine (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane ; Peripheral membrane protein : O94804
• Total number of polymer chains: 2
• Total formula weight: 69564.37

Authors

Elkins, J.M.,Salah, E.,Szklarz, M.,von Delft, F.,Canning, P.,Raynor, J.,Bountra, C.,Edwards, A.M.,Knapp, S. (deposition date: 2014-07-07, release date: 2015-07-22, Last modification date: 2018-01-24)

• Primary citation: Elkins, J.M.,Fedele, V.,Szklarz, M.,Abdul Azeez, K.R.,Salah, E.,Mikolajczyk, J.,Romanov, S.,Sepetov, N.,Huang, X.P.,Roth, B.L.,Al Haj Zen, A.,Fourches, D.,Muratov, E.,Tropsha, A.,Morris, J.,Teicher, B.A.,Kunkel, M.,Polley, E.,Lackey, K.E.,Atkinson, F.L.,Overington, J.P.,Bamborough, P.,Moller, S.,Price, D.J.,Willson, T.M.,Drewry, D.H.,Knapp, S.,Zuercher, W.J.; Comprehensive Characterization of the Published Kinase Inhibitor Set.; Nat.Biotechnol., 34:95-, 2016; PubMed: 26501955; DOI: 10.1038/NBT.3374

Experimental method

X-RAY DIFFRACTION (2.65 Å)