4URM

Crystal Structure of Staph GyraseB 24kDa in complex with Kibdelomycin

4URM の概要

• エントリーDOI: 10.2210/pdb4urm/pdb
• 関連するPDBエントリー: 4URL 4URN 4URO
• 分子名称: DNA GYRASE SUBUNIT B, (1R,4aS,5S,6S,8aR)-5-{[(5S)-1-(3-O-acetyl-4-O-carbamoyl-6-deoxy-2-O-methyl-alpha-L-talopyranosyl)-4-hydroxy-2-oxo-5-(propan-2-yl)-2,5-dihydro-1H-pyrrol-3-yl]carbonyl}-6-methyl-4-methylidene-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl 2,6-dideoxy-3-C-[(1S)-1-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}ethyl]-beta-D-ribo-hexopyranoside (3 entities in total)
• 機能のキーワード: isomerase, antibiotics, gyrase, topoisomerase iv, natural product
• 由来する生物種: STAPHYLOCOCCUS AUREUS
• 細胞内の位置: Cytoplasm (Potential): P0A0K8
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106513.96

構造登録者

Lu, J.,Patel, S.,Sharma, N.,Soisson, S.,Kishii, R.,Takei, M.,Fukuda, Y.,Lumb, K.J.,Singh, S.B. (登録日: 2014-06-30, 公開日: 2014-07-30, 最終更新日: 2024-05-08)

• 主引用文献: Lu, J.,Patel, S.,Sharma, N.,Soisson, S.M.,Kishii, R.,Takei, M.,Fukuda, Y.,Lumb, K.J.,Singh, S.B.; Structures of Kibdelomycin Bound to Staphylococcus Aureus Gyrb and Pare Showed a Novel U-Shaped Binding Mode.; Acs Chem.Biol., 9:2023-, 2014; PubMed: 24992706; DOI: 10.1021/CB5001197

実験手法

X-RAY DIFFRACTION (2.94 Å)