4URK
PI3Kg in complex with AZD6482
Summary for 4URK
Entry DOI | 10.2210/pdb4urk/pdb |
Descriptor | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid (2 entities in total) |
Functional Keywords | transferase, lipid kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 111135.55 |
Authors | Giordanetto, F.,Barlaam, B.,Berglund, S.,Edman, K.,Karlsson, O.,Lindberg, J.,Nylander, S.,Inghardt, T. (deposition date: 2014-06-30, release date: 2014-10-22, Last modification date: 2024-01-10) |
Primary citation | Giordanetto, F.,Barlaam, B.,Berglund, S.,Edman, K.,Karlsson, O.,Lindberg, J.,Nylander, S.,Inghardt, T. Discovery of 9-(1-Phenoxyethyl)-2-Morpholino-4-Oxo-Pyrido[1, 2-A]Pyrimidine-7-Carboxamides as Oral Pi3Kbeta Inhibitors, Useful as Antiplatelet Agents. Bioorg.Med.Chem.Lett., 24:3936-, 2014 Cited by PubMed: 25042253DOI: 10.1016/J.BMCL.2014.07.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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