4UMA

Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3 deoxy D arabino heptulosonate 7 phosphate synthase the importance of accommodating the active site water

Summary for 4UMA

Entry DOI	10.2210/pdb4uma/pdb
Related	4UMB 4UMC
Descriptor	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, MANGANESE (II) ION, (E)-2-METHYL-3-PHOSPHONOACRYLATE, ... (4 entities in total)
Functional Keywords	transferase, dah7ps, dahps, aromatic amino acids, shikimate pathway, oxocarbenium ion, enzyme inhibitors, meningitis
Biological source	NEISSERIA MENINGITIDIS
Total number of polymer chains	4
Total formula weight	155732.56
Authors	Heyes, L.C.,Reichau, S.,Cross, P.J.,Parker, E.J. (deposition date: 2014-05-16, release date: 2014-10-08, Last modification date: 2024-01-10)
Primary citation	Heyes, L.C.,Reichau, S.,Cross, P.J.,Jameson, G.B.,Parker, E.J. Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water. Bioorg.Chem., 57:242-, 2014 Cited by PubMed: 25245459 DOI: 10.1016/J.BIOORG.2014.08.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation