4UMA
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3 deoxy D arabino heptulosonate 7 phosphate synthase the importance of accommodating the active site water
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009058 | biological_process | biosynthetic process |
A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
A | 0009423 | biological_process | chorismate biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009058 | biological_process | biosynthetic process |
B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
B | 0009423 | biological_process | chorismate biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0046872 | molecular_function | metal ion binding |
C | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0009058 | biological_process | biosynthetic process |
C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
C | 0009423 | biological_process | chorismate biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
C | 0046872 | molecular_function | metal ion binding |
D | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0008652 | biological_process | amino acid biosynthetic process |
D | 0009058 | biological_process | biosynthetic process |
D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
D | 0009423 | biological_process | chorismate biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 1350 |
Chain | Residue |
A | CYS63 |
A | HIS270 |
A | GLU304 |
A | ASP324 |
A | GZ31351 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B 1350 |
Chain | Residue |
B | GZ31351 |
B | CYS63 |
B | HIS270 |
B | GLU304 |
B | ASP324 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN C 1350 |
Chain | Residue |
C | CYS63 |
C | HIS270 |
C | GLU304 |
C | ASP324 |
C | GZ31351 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN D 1350 |
Chain | Residue |
D | CYS63 |
D | HIS270 |
D | GLU304 |
D | ASP324 |
D | GZ31351 |
site_id | AC5 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE GZ3 D 1351 |
Chain | Residue |
D | CYS63 |
D | ARG94 |
D | TYR96 |
D | LYS99 |
D | GLY165 |
D | ALA166 |
D | ARG167 |
D | LYS188 |
D | ARG236 |
D | HIS270 |
D | GLU304 |
D | ASP324 |
D | MN1350 |
D | HOH2070 |
D | HOH2083 |
D | HOH2085 |
D | HOH2142 |
site_id | AC6 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE GZ3 C 1351 |
Chain | Residue |
C | CYS63 |
C | ARG94 |
C | TYR96 |
C | LYS99 |
C | GLY165 |
C | ALA166 |
C | ARG167 |
C | LYS188 |
C | ARG236 |
C | HIS270 |
C | GLU304 |
C | ASP324 |
C | MN1350 |
C | HOH2049 |
C | HOH2086 |
C | HOH2104 |
C | HOH2109 |
site_id | AC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE GZ3 B 1351 |
Chain | Residue |
B | CYS63 |
B | ARG94 |
B | TYR96 |
B | LYS99 |
B | GLY165 |
B | ALA166 |
B | ARG167 |
B | LYS188 |
B | ARG236 |
B | HIS270 |
B | GLU304 |
B | MN1350 |
B | HOH2069 |
B | HOH2108 |
B | HOH2122 |
B | HOH2124 |
site_id | AC8 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GZ3 A 1351 |
Chain | Residue |
A | CYS63 |
A | ARG94 |
A | TYR96 |
A | LYS99 |
A | GLY165 |
A | ALA166 |
A | ARG167 |
A | LYS188 |
A | ARG236 |
A | HIS270 |
A | GLU304 |
A | ASP324 |
A | MN1350 |
A | HOH2068 |
A | HOH2115 |
A | HOH2131 |
A | HOH2136 |
A | HOH2219 |