4UG2

Thermostabilised HUMAN A2a Receptor with CGS21680 bound

Summary for 4UG2

• Entry DOI: 10.2210/pdb4ug2/pdb
• Descriptor: THERMOSTABILISED HUMAN A2A RECEPTOR, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, ... (4 entities in total)
• Functional Keywords: signaling protein, g seven-helix receptor, integral membrane protein, agonist bound form, thermostabilising point mutations, gpcr, 7tm receptor
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 73757.67

Authors

Lebon, G.,Edwards, P.C.,Leslie, A.G.W.,Tate, C.G. (deposition date: 2015-03-21, release date: 2015-04-08, Last modification date: 2023-12-20)

• Primary citation: Lebon, G.,Edwards, P.C.,Leslie, A.G.W.,Tate, C.G.; Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.; Mol.Pharmacol., 87:907-, 2015; PubMed: 25762024; DOI: 10.1124/MOL.114.097360

Experimental method

X-RAY DIFFRACTION (2.6 Å)