4UG2

Thermostabilised HUMAN A2a Receptor with CGS21680 bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
B	0001609	molecular_function	G protein-coupled adenosine receptor activity
B	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
B	0004930	molecular_function	G protein-coupled receptor activity
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLB A 1310

Chain	Residue
A	TRP143
A	ASN144
A	ASN145
A	PRO173
A	ASN175
B	ARG111
B	LEU115

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NGI A 1311

Chain	Residue
A	LEU85
A	THR88
A	PHE168
A	GLU169
A	MET177
A	ASN181
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	HIS264
A	LEU267
A	MET270
A	ILE274
A	SER277
A	HIS278
A	HOH2002
A	SER67
A	VAL84

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OLB B 1306

Chain	Residue
A	ILE108
B	TRP143
B	ASN144
B	ASN145
B	TYR179

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE NGI B 1307

Chain	Residue
B	SER67
B	VAL84
B	LEU85
B	THR88
B	PHE168
B	GLU169
B	MET177
B	ASN181
B	TRP246
B	LEU249
B	HIS250
B	ASN253
B	HIS264
B	LEU267
B	MET270
B	SER277
B	HIS278
B	HOH2003

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:18832607

Chain	Residue	Details
A	MET1-SER7
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266
B	MET1-SER7
B	SER67-CYS77
B	ASN144-PRO173
B	CYS259-PRO266

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32
B	VAL8-TRP32

---

site_id	SWS_FT_FI3
Number of Residues	126
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120
A	ARG199-SER234
B	LEU33-ASN42
B	ASP101-ARG120
B	ARG199-SER234

---

site_id	SWS_FT_FI4
Number of Residues	46
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66
B	TYR43-ILE66

---

site_id	SWS_FT_FI5
Number of Residues	44
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100
B	LEU78-ILE100

---

site_id	SWS_FT_FI6
Number of Residues	44
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143
B	ALA121-TRP143

---

site_id	SWS_FT_FI7
Number of Residues	48
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198
B	MET174-LEU198

---

site_id	SWS_FT_FI8
Number of Residues	46
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU235-PHE258
B	LEU235-PHE258

---

site_id	SWS_FT_FI9
Number of Residues	46
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290
B	LEU267-TYR290

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	SER277
A	HIS278
B	GLU169
B	ASN253
B	SER277
B	HIS278

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ALA154
B	ALA154

---