4UF0

Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid.

Summary for 4UF0

• Entry DOI: 10.2210/pdb4uf0/pdb
• Descriptor: HISTONE DEMETHYLASE UTY, FE (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ... (7 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus : O14607 O14607
• Total number of polymer chains: 2
• Total formula weight: 112124.41

Authors

Srikannathasan, V.,Johansson, C.,Gileadi, C.,Tobias, K.,Kopec, J.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U. (deposition date: 2014-12-22, release date: 2015-01-14, Last modification date: 2023-12-20)

• Primary citation: Johansson, C.,Velupillai, S.,Tumber, A.,Szykowska, A.,Hookway, E.S.,Nowak, R.P.,Strain-Damerell, C.,Gileadi, C.,Philpott, M.,Burgess-Brown, N.,Wu, N.,Kopec, J.,Nuzzi, A.,Steuber, H.,Egner, U.,Badock, V.,Munro, S.,Lathangue, N.B.,Westaway, S.,Brown, J.,Athanasou, N.,Prinjha, R.,Brennan, P.E.,Oppermann, U.; Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.; Nat.Chem.Biol., 12:539-, 2016; PubMed: 27214403; DOI: 10.1038/NCHEMBIO.2087

Experimental method

X-RAY DIFFRACTION (1.78 Å)