4UDW

Thrombin in complex with 1-(2R)-2-amino-3-phenyl-propanoyl-N-(2, 5dichlorophenyl)methylpyrrolidine-2-carboxamide

4UDW の概要

• エントリーDOI: 10.2210/pdb4udw/pdb
• 関連するPDBエントリー: 4UD9 4UDH 4UE7
• 分子名称: THROMBIN HEAVY CHAIN, HIRUDIN VARIANT-2, THROMBIN LIGHT CHAIN, ... (9 entities in total)
• 機能のキーワード: hydrolase, hydrolase inhibitor complex, serine protease, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, fragment, glycosylation, blood
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35334.96

構造登録者

Ruehmann, E.,Heine, A.,Klebe, G. (登録日: 2014-12-12, 公開日: 2015-08-26, 最終更新日: 2023-12-20)

• 主引用文献: Ruehmann, E.,Betz, M.,Heine, A.,Klebe, G.; Fragments Can Bind Either More Enthalpy or Entropy-Driven: Crystal Structures and Residual Hydration Pattern Suggest Why.; J.Med.Chem., 58:6960-, 2015; PubMed: 26270568; DOI: 10.1021/ACS.JMEDCHEM.5B00812

実験手法

X-RAY DIFFRACTION (1.16 Å)