4UCO

Fragment bound to H.influenza NAD dependent DNA ligase

Summary for 4UCO

Entry DOI	10.2210/pdb4uco/pdb
Related	4UCR 4UCS 4UCT 4UCU 4UCV
Descriptor	DNA LIGASE, 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, ... (4 entities in total)
Functional Keywords	ligase
Biological source	HAEMOPHILUS INFLUENZAE
Total number of polymer chains	1
Total formula weight	37080.00
Authors	Hale, M.,Brassington, C.,Carcanague, D.,Embrey, K.,Eyermann, C.J.,Giacobbe, R.A.,Gingipali, L.,Gowravaram, M.,Harang, J.,Howard, T.,Ioannidis, G.,Jahic, H.,Kutschke, A.,Laganas, V.A.,Loch, J.,Miller, M.D.,Murphy-Benenato, K.E.,Oguto, H.,Otterbein, L.,Patel, S.J.,Shapiro, A.B.,Boriack-Sjodin, P.A. (deposition date: 2014-12-04, release date: 2015-10-14, Last modification date: 2024-05-08)
Primary citation	Hale, M.,Brassington, C.,Carcanague, D.,Embrey, K.,Eyermann, C.J.,Giacobbe, R.A.,Gingipali, L.,Gowravaram, M.,Harang, J.,Howard, T.,Ioannidis, G.,Jahic, H.,Kutschke, A.,Laganas, V.A.,Loch, J.,Miller, M.D.,Murphy-Benenato, K.E.,Oguto, H.,Otterbein, L.,Patel, S.J.,Shapiro, A.B.,Boriack-Sjodin, P.A. From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56:3108-, 2015 Cited by DOI: 10.1016/J.TETLET.2014.12.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation