4UBS
The crystal structure of cytochrome P450 105D7 from Streptomyces avermitilis in complex with Diclofenac
Summary for 4UBS
Entry DOI | 10.2210/pdb4ubs/pdb |
Descriptor | Pentalenic acid synthase, PROTOPORPHYRIN IX CONTAINING FE, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ... (7 entities in total) |
Functional Keywords | cytochrome p450, diclofenac, hydroxylation, oxidoreductase |
Biological source | Streptomyces avermitilis MA-4680 = NBRC 14893 |
Total number of polymer chains | 1 |
Total formula weight | 46814.57 |
Authors | Xu, L.H.,Ikeda, H.,Arakawa, T.,Wakagi, T.,Shoun, H.,Fushinobu, S. (deposition date: 2014-08-13, release date: 2014-11-05, Last modification date: 2024-03-20) |
Primary citation | Xu, L.H.,Ikeda, H.,Liu, L.,Arakawa, T.,Wakagi, T.,Shoun, H.,Fushinobu, S. Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase. Appl.Microbiol.Biotechnol., 99:3081-3091, 2015 Cited by PubMed: 25341403DOI: 10.1007/s00253-014-6148-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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