4U82

Structure of S. aureus undecaprenyl diphosphate synthase in complex with FSPP and sulfate

Summary for 4U82

Entry DOI	10.2210/pdb4u82/pdb
Descriptor	Isoprenyl transferase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ... (5 entities in total)
Functional Keywords	alkyl and aryl transferases, anti-bacterial agents, benzoates, biosynthetic pathways, cell wall, diphosphonates, drug discovery, high-throughput screening assays, methicillin, microbial sensitivity tests, pyrrolidinones, staphylococcus aureus, terpenes, transferase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	30420.96
Authors	Zhu, W.,Oldfield, E. (deposition date: 2014-07-31, release date: 2015-02-04, Last modification date: 2023-09-27)
Primary citation	Zhu, W.,Wang, Y.,Li, K.,Gao, J.,Huang, C.H.,Chen, C.C.,Ko, T.P.,Zhang, Y.,Guo, R.T.,Oldfield, E. Antibacterial drug leads: DNA and enzyme multitargeting. J.Med.Chem., 58:1215-1227, 2015 Cited by PubMed: 25574764 DOI: 10.1021/jm501449u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation