4U7T

Crystal structure of DNMT3A-DNMT3L in complex with histone H3

Summary for 4U7T

• Entry DOI: 10.2210/pdb4u7t/pdb
• Related: 4U7P
• Descriptor: DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, peptide from Histone H3.3, ... (6 entities in total)
• Functional Keywords: dna methyltransferase, active form, transferase-transferase regulator complex, transferase/transferase regulator
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9Y6K1 Q9UJW3 P84243
• Total number of polymer chains: 6
• Total formula weight: 153774.43

Authors

Guo, X.,Wang, L.,Yin, X.,Li, J.,Xiao, J.,He, S.,Wang, J.,Xu, Y. (deposition date: 2014-07-31, release date: 2014-11-12, Last modification date: 2023-11-08)

• Primary citation: Guo, X.,Wang, L.,Li, J.,Ding, Z.,Xiao, J.,Yin, X.,He, S.,Shi, P.,Dong, L.,Li, G.,Tian, C.,Wang, J.,Cong, Y.,Xu, Y.; Structural insight into autoinhibition and histone H3-induced activation of DNMT3A; Nature, 517:640-644, 2015; PubMed: 25383530; DOI: 10.1038/nature13899

Experimental method

X-RAY DIFFRACTION (2.9 Å)