4U41

MAP4K4 Bound to inhibitor compound 1

Summary for 4U41

• Entry DOI: 10.2210/pdb4u41/pdb
• Related: 4U3Y 4U3Z 4U40 4U42 4U43 4U44 4U45
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 4, 6-[(3S)-3-(4-methyl-1H-pyrazol-3-yl)piperidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : O95819
• Total number of polymer chains: 2
• Total formula weight: 76269.07

Authors

Harris, S.F.,Wu, P.,Coons, M. (deposition date: 2014-07-23, release date: 2016-01-06, Last modification date: 2023-12-27)

• Primary citation: Wu, P.,Chen, H.,Coons, M.,Crawford, T.D.,Kirkpatrick, D.S.,Murray, L.,Ndubaku, C.O.,Nonomiya, J.,Pham, V.,Schmidt, S.,Smysczek, T.,Vitorino, P.,Ye, W.,Harris, S.F.; Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures; to be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)