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4U41

MAP4K4 Bound to inhibitor compound 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 3C8 A 401
ChainResidue
ATYR36
ALEU160
AVAL170
AVAL39
AALA52
ALYS54
ALEU103
AMET105
AGLU106
APHE107
ACYS108

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 402
ChainResidue
ASER77
AHIS79
AILE82
ATHR84
AHOH533
AHOH580

site_idAC3
Number of Residues9
Detailsbinding site for residue MES A 403
ChainResidue
AGLN276
AGLN282
AASP307
AARG308
AHOH509
AHOH514
AHOH531
BMET275
BGLN276

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGNGTYGQVYkGrhvktgql..........AAIK
ChainResidueDetails
AVAL31-LYS54

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKgqNVLL
ChainResidueDetails
AVAL149-LEU161

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP153
BASP153

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AVAL31
ALYS54
BVAL31
BLYS54

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER5
BSER5

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97820
ChainResidueDetails
ASER324
ASER326
BSER324
BSER326

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PDB entries from 2024-05-01

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