4U3D

LpxC from A.Aaeolicus in complex with 4-[[4-[2-[4-(morpholinomethyl)phenyl]ethynyl]phenoxy]methyl]tetrahydropyran-4-carbohydroxamic acid (compound 9)

4U3D の概要

• エントリーDOI: 10.2210/pdb4u3d/pdb
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, IMIDAZOLE, ZINC ION, ... (6 entities in total)
• 機能のキーワード: antibacterial, lpxc, gram negative bacteria, mmp, hydrophobe, hydrolase
• 由来する生物種: Aquifex aeolicus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31675.39

構造登録者

Olivier, N.B. (登録日: 2014-07-19, 公開日: 2014-10-01, 最終更新日: 2023-12-20)

• 主引用文献: Murphy-Benenato, K.E.,Olivier, N.,Choy, A.,Ross, P.L.,Miller, M.D.,Thresher, J.,Gao, N.,Hale, M.R.; Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.; Acs Med.Chem.Lett., 5:1213-1218, 2014; PubMed: 25408833; DOI: 10.1021/ml500210x

実験手法

X-RAY DIFFRACTION (1.25 Å)