4U30
Human mesotrypsin complexed with bikunin Kunitz domain 2
Summary for 4U30
Entry DOI | 10.2210/pdb4u30/pdb |
Related | 4U32 |
Descriptor | Trypsin-3, Trypstatin, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | serine protease, protease inhibitor, protein-protein interaction, protein degradation, proteolysis, substrate specificity, enzyme kinetics, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P35030 P02760 |
Total number of polymer chains | 8 |
Total formula weight | 123008.17 |
Authors | Wang, R.,Soares, A.S.,Radisky, E.S. (deposition date: 2014-07-18, release date: 2014-10-15, Last modification date: 2023-12-27) |
Primary citation | Pendlebury, D.,Wang, R.,Henin, R.D.,Hockla, A.,Soares, A.S.,Madden, B.J.,Kazanov, M.D.,Radisky, E.S. Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN. J.Biol.Chem., 289:32783-32797, 2014 Cited by PubMed: 25301953DOI: 10.1074/jbc.M114.609560 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report