4U2X
Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus
Summary for 4U2X
Entry DOI | 10.2210/pdb4u2x/pdb |
Descriptor | Membrane-associated protein VP24, Importin subunit alpha-6, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | evp24, importin alpha6, immune antagonist, viral protein |
Biological source | Zaire ebolavirus (ZEBOV) More |
Total number of polymer chains | 6 |
Total formula weight | 131767.07 |
Authors | Xu, W.,Leung, D.,Borek, D.,Amarasinghe, G. (deposition date: 2014-07-18, release date: 2014-08-13, Last modification date: 2023-12-27) |
Primary citation | Xu, W.,Edwards, M.R.,Borek, D.M.,Feagins, A.R.,Mittal, A.,Alinger, J.B.,Berry, K.N.,Yen, B.,Hamilton, J.,Brett, T.J.,Pappu, R.V.,Leung, D.W.,Basler, C.F.,Amarasinghe, G.K. Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host Microbe, 16:187-200, 2014 Cited by PubMed: 25121748DOI: 10.1016/j.chom.2014.07.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.153 Å) |
Structure validation
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