4TYH

Ternary complex of P38 and MK2 with a P38 inhibitor

Summary for 4TYH

• Entry DOI: 10.2210/pdb4tyh/pdb
• Related: 4TYK
• Descriptor: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide, ... (4 entities in total)
• Functional Keywords: p38, mk2, p38 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : P49137 P47811
• Total number of polymer chains: 2
• Total formula weight: 80668.96

Authors

Cumming, J.G.,Debreczeni, J.E.,Edfeldt, F.,Evertsson, F.,Harrison, M.,Holdgate, G.,James, M.,Lamont, S.,Oldham, K.,Sullivan, J.E.,Wells, S. (deposition date: 2014-07-08, release date: 2015-07-22, Last modification date: 2023-12-27)

• Primary citation: Cumming, J.G.; Discovery of substrate selective, ATP-competitive P38 alpha MAP kinase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (3 Å)