4TY1

Crystal structure of human Pim-1 kinase in complex with an aminooxadiazole-indole inhibitor.

Summary for 4TY1

• Entry DOI: 10.2210/pdb4ty1/pdb
• Descriptor: Serine/threonine-protein kinase pim-1, N-tert-butyl-5-[3-(4-cyclopropylpyrimidin-2-yl)-1H-indol-5-yl]-1,3,4-oxadiazol-2-amine, GLYCEROL, ... (4 entities in total)
• Functional Keywords: transferase, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 33530.95

Authors

Mohr, C. (deposition date: 2014-07-07, release date: 2015-02-04, Last modification date: 2023-12-27)

• Primary citation: Wurz, R.P.,Pettus, L.H.,Jackson, C.,Wu, B.,Wang, H.L.,Herberich, B.,Cee, V.,Lanman, B.A.,Reed, A.B.,Chavez, F.,Nixey, T.,Laszlo, J.,Wang, P.,Nguyen, Y.,Sastri, C.,Guerrero, N.,Winston, J.,Lipford, J.R.,Lee, M.R.,Andrews, K.L.,Mohr, C.,Xu, Y.,Zhou, Y.,Reid, D.L.,Tasker, A.S.; The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.; Bioorg.Med.Chem.Lett., 25:847-855, 2015; PubMed: 25599837; DOI: 10.1016/j.bmcl.2014.12.067

Experimental method

X-RAY DIFFRACTION (2.7 Å)