4TWO

Human EphA3 Kinase domain in complex with compound 164

Summary for 4TWO

Entry DOI	10.2210/pdb4two/pdb
Descriptor	Ephrin type-A receptor 3, 5-{[3-carbamoyl-4-(3,4-dimethylphenyl)-5-methylthiophen-2-yl]amino}-5-oxopentanoic acid (3 entities in total)
Functional Keywords	transferase/transferase inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P29320
Total number of polymer chains	1
Total formula weight	40832.63
Authors	Dong, J.,Caflisch, A. (deposition date: 2014-07-01, release date: 2015-05-13, Last modification date: 2023-12-20)
Primary citation	Dong, J.,Zhao, H.,Zhou, T.,Spiliotopoulos, D.,Rajendran, C.,Li, X.D.,Huang, D.,Caflisch, A. Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases. Acs Med.Chem.Lett., 6:79-83, 2015 Cited by PubMed: 25589935 DOI: 10.1021/ml500355x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.047 Å)

Structure validation