4TWO

Human EphA3 Kinase domain in complex with compound 164

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ephrin type-A receptor 3	polymer	361	40458.2	1	UniProt (P29320) Pfam (PF07714) Pfam (PF07647) In PDB	Homo sapiens (Human)	EPH-like kinase 4,hEK4,HEK,Human embryo kinase,Tyrosine-protein kinase TYRO4,Tyrosine-protein kinase receptor ETK1,Eph-like tyrosine kinase 1
2	A	5-{[3-carbamoyl-4-(3,4-dimethylphenyl)-5-methylthiophen-2-yl]amino}-5-oxopentanoic acid	non-polymer		374.5	1	Chemie (37W)
3		water	water		18.0	186	Chemie (HOH)

Sequence modifications

A: 609 - 947 (UniProt: P29320)

PDB	External Database	Details
Met 587	-	initiating methionine
Gly 588	-	expression tag
Ser 589	-	expression tag
Ser 590	-	expression tag
His 591	-	expression tag
His 592	-	expression tag
His 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
Ser 597	-	expression tag
Ser 598	-	expression tag
Gly 599	-	expression tag
Leu 600	-	expression tag
Val 601	-	expression tag
Pro 602	-	expression tag
Arg 603	-	expression tag
Gly 604	-	expression tag
Ser 605	-	expression tag
Thr 606	-	expression tag
Gln 607	-	expression tag
Thr 608	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40458.2
Non-Polymers*	Number of molecules	1
	Total formula weight	374.5
All*	Total formula weight	40832.6

*Water molecules are not included.