4TWK

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Summary for 4TWK

DescriptorPotassium channel subfamily K member 2, POTASSIUM ION, Octyl Glucose Neopentyl Glycol, ... (6 entities in total)
Functional Keywordsion channel, membrane protein, k2p, transport protein
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 1: Cell membrane; Multi-pass membrane protein (By similarity). Isoform 2: Cell membrane; Multi-pass membrane protein (By similarity). Isoform 4: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity) O95069
Total number of polymer chains2
Total molecular weight65665.15
Authors
Primary citation
Pike, A.C.W.,Dong, Y.Y.,Tessitore, A.,Goubin, S.,Strain-Damerell, C.,Mukhopadhyay, S.,Kupinska, K.,Wang, D.,Chalk, R.,Berridge, G.,Grieben, M.,Shrestha, L.,Ang, J.H.,Mackenzie, A.,Quigley, A.,Bushell, S.R.,Shintre, C.A.,Faust, B.,Chu, A.,Dong, L.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Burgess-Brown, N.A.,Carpenter, E.P.
Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.272200.5%13.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution