4TWF

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromomemantine

Summary for 4TWF

• Entry DOI: 10.2210/pdb4twf/pdb
• Descriptor: Cys-loop ligand-gated ion channel, Bromomemantine (2 entities in total)
• Functional Keywords: elic, lgic, cys-loop, channel, memantine, pore blocker, transport protein
• Biological source: Dickeya chrysanthemi (Pectobacterium chrysanthemi)
• Cellular location: Cell inner membrane ; Multi- pass membrane protein : P0C7B7
• Total number of polymer chains: 10
• Total formula weight: 355910.29

Authors

Ulens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Lu, H.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C.R. (deposition date: 2014-06-30, release date: 2014-09-24, Last modification date: 2023-12-20)

• Primary citation: Ulens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Han, L.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C.; The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.; Structure, 22:1399-1407, 2014; PubMed: 25199693; DOI: 10.1016/j.str.2014.07.013

Experimental method

X-RAY DIFFRACTION (3.901 Å)