4TWF
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromomemantine
Summary for 4TWF
Entry DOI | 10.2210/pdb4twf/pdb |
Descriptor | Cys-loop ligand-gated ion channel, Bromomemantine (2 entities in total) |
Functional Keywords | elic, lgic, cys-loop, channel, memantine, pore blocker, transport protein |
Biological source | Dickeya chrysanthemi (Pectobacterium chrysanthemi) |
Cellular location | Cell inner membrane ; Multi- pass membrane protein : P0C7B7 |
Total number of polymer chains | 10 |
Total formula weight | 355910.29 |
Authors | Ulens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Lu, H.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C.R. (deposition date: 2014-06-30, release date: 2014-09-24, Last modification date: 2023-12-20) |
Primary citation | Ulens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Han, L.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C. The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine. Structure, 22:1399-1407, 2014 Cited by PubMed: 25199693DOI: 10.1016/j.str.2014.07.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.901 Å) |
Structure validation
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