Summary for 4TTH
Entry DOI | 10.2210/pdb4tth/pdb |
Descriptor | Cyclin homolog, Cyclin-dependent kinase 6, 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | kinase, transferase-cell cycle-inhibitor complex, transferase/cell cycle/inhibitor |
Biological source | Saimiriine herpesvirus 2 (SaHV-2) More |
Cellular location | Cytoplasm: Q00534 |
Total number of polymer chains | 2 |
Total formula weight | 66067.25 |
Authors | Piper, D.E.,Walker, N.,Wang, Z. (deposition date: 2014-06-20, release date: 2014-08-06, Last modification date: 2023-09-27) |
Primary citation | Li, Z.,Wang, X.,Eksterowicz, J.,Gribble, M.W.,Alba, G.Q.,Ayres, M.,Carlson, T.J.,Chen, A.,Chen, X.,Cho, R.,Connors, R.V.,DeGraffenreid, M.,Deignan, J.T.,Duquette, J.,Fan, P.,Fisher, B.,Fu, J.,Huard, J.N.,Kaizerman, J.,Keegan, K.S.,Li, C.,Li, K.,Li, Y.,Liang, L.,Liu, W.,Lively, S.E.,Lo, M.C.,Ma, J.,McMinn, D.L.,Mihalic, J.T.,Modi, K.,Ngo, R.,Pattabiraman, K.,Piper, D.E.,Queva, C.,Ragains, M.L.,Suchomel, J.,Thibault, S.,Walker, N.,Wang, X.,Wang, Z.,Wanska, M.,Wehn, P.M.,Weidner, M.F.,Zhang, A.J.,Zhao, X.,Kamb, A.,Wickramasinghe, D.,Dai, K.,McGee, L.R.,Medina, J.C. Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. J.Med.Chem., 57:3430-3449, 2014 Cited by PubMed: 24641103DOI: 10.1021/jm500118j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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