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4TTH

Crystal structure of a CDK6/Vcyclin complex with inhibitor bound

Replaces:  4P41
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Cyclin homologpolymer25428665.41UniProt (Q01043)
Pfam (PF00134)
Pfam (PF09241)
Saimiriine herpesvirus 2 (SaHV-2)V-cyclin
2B
(B)
Cyclin-dependent kinase 6polymer32636987.31UniProt (Q00534)
Pfam (PF00069)
Homo sapiens (Human)Cell division protein kinase 6,Serine/threonine-protein kinase PLSTIRE
3C
(B)
9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-aminenon-polymer414.51Chemie (24V)
4D, E
(A, B)
waterwater18.010Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight65652.7
Non-Polymers*Number of molecules1
Total formula weight414.5
All*Total formula weight66067.3
*Water molecules are not included.

239149

PDB entries from 2025-07-23

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