4TT7

Crystal structure of human ALK with a covalent modification

Summary for 4TT7

Entry DOI	10.2210/pdb4tt7/pdb
Descriptor	ALK tyrosine kinase receptor, 1-THIOETHANESULFONIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	atp-binding, receptor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : Q9UM73
Total number of polymer chains	1
Total formula weight	37240.79
Authors	Badger, J.,Sridhar, V.,Chie-Leon, B.,Nienaber, V.L.,Hausheer, F.H. (deposition date: 2014-06-19, release date: 2015-02-11, Last modification date: 2023-09-27)
Primary citation	Parker, A.R.,Petluru, P.N.,Nienaber, V.L.,Zhao, M.,Ayala, P.Y.,Badger, J.,Chie-Leon, B.,Sridhar, V.,Logan, C.,Kochat, H.,Hausheer, F.H. Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787. Onco Targets Ther, 8:375-383, 2015 Cited by PubMed: 25678804 DOI: 10.2147/OTT.S73690 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation