4TSD
Crystal structure of Helicobacter pylori HP1029
Summary for 4TSD
| Entry DOI | 10.2210/pdb4tsd/pdb |
| Related | 4TSZ |
| Descriptor | HP1029, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total) |
| Functional Keywords | unknown function, pfam family pf04074, zinc binding |
| Biological source | Helicobacter pylori 26695 |
| Total number of polymer chains | 2 |
| Total formula weight | 44946.23 |
| Authors | Vallese, F.,Percudani, R.,Zanotti, G. (deposition date: 2014-06-18, release date: 2015-06-10, Last modification date: 2023-12-20) |
| Primary citation | Vallese, F.,Percudani, R.,Fischer, W.,Zanotti, G. The crystal structure of Helicobacter pylori HP1029 highlights the functional diversity of the sialic acid-related DUF386 family. Febs J., 282:3311-3322, 2015 Cited by PubMed Abstract: The proteins of the YhcH/YjgK/YiaL (DUF386) family have been implicated in the bacterial metabolism of host-derived sialic acids and biofilm formation, although their precise biochemical function remains enigmatic. We present here the crystal structure of protein HP1029 from Helicobacter pylori. The protein is a homodimer, in which each monomer comprises a molecular core formed by 12 antiparallel β-strands arranged in two β-sheets flanked by helices. The sandwich formed by the sheets assumes the shape of a funnel opened at one end, with a zinc ion present at the bottom of the funnel. The crystal structure unequivocally shows that HP1029 belongs to the DUF386 family. Although no bioinformatics evidence has been found for sialic acid catabolism in H. pylori, the genomic context of HP1029 in Helicobacter and related organisms suggests a possible role in the metabolism of bacterial surface saccharides, such as pseudaminic acid and its derivatives. PubMed: 26096900DOI: 10.1111/febs.13344 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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