4TQ8

Dual binding mode for 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid binding to Human transthyretin (TTR)

4TQ8 の概要

• エントリーDOI: 10.2210/pdb4tq8/pdb
• 関連するPDBエントリー: 3GS0 3GS4 4TQH 4TQI
• 分子名称: Transthyretin, 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: ttr, inhibitor 15, forward and reverse binding modes, amyloid inhibitor, polyethylene glycol crystallization, hormone
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28213.41

構造登録者

Ciccone, L.,Orlandini, E.,Nencetti, S.,Rossello, A.,Stura, E.A. (登録日: 2014-06-10, 公開日: 2015-06-24, 最終更新日: 2023-12-27)

• 主引用文献: Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E.; X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors.; J Enzyme Inhib Med Chem, :1-10, 2015; PubMed: 26235916

実験手法

X-RAY DIFFRACTION (1.52 Å)